Cancer. Silencing a metabolic oncogene.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23641103.
- Also identified by DOI 10.1126/science.1238523 and PMC identifier 4324171.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Small molecules inhibit a mutant enzyme confined to tumors, supporting therapeutic approaches that can reprogram metabolism in cancer.
Medical subject headings
- Benzeneacetamides
- Cell Differentiation
- Cell Transformation, Neoplastic
- Enzyme Inhibitors
- Glioma
- Glutarates
- Hematopoiesis
- Imidazoles
- Isocitrate Dehydrogenase
- Leukemia
- Leukemia, Myeloid, Acute
- Phenylurea Compounds
- Procollagen-Proline Dioxygenase
- Sulfonamides