miR-34a sets the "sweet spot" for notch in colorectal cancer stem cells.
editorial · Level V
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- Record sourced from PubMed, PMID 23642356.
- Also identified by DOI 10.1016/j.stem.2013.04.018.
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Abstract
Mechanisms underlying alternative modes of symmetric versus asymmetric stem cell fates are not well understood. In this issue of Cell Stem Cell, Bu et al. (2013) find that miR-34a acts as a toggle switch for Notch signaling that dictates binary symmetric and asymmetric fates in colon cancer stem cells.