Pedunculated serrated polyp with histologic features of sessile serrated adenoma: a clinicopathologic and molecular study.

Abstract

In this study, we describe a previously undescribed pedunculated serrated polyp of the colon showing typical features of sessile serrated adenoma/polyp (SSA/P). All polyps were pedunculated, located in the proximal colon, small in size, and occurred in elderly patients. Histologically, the polyps showed typical features of SSA/P in the basal crypts with irregular, asymmetric expression of Ki-67. All polyps showed the BRAF-V600E mutation. The cells in the polyps did not show obvious cytologic dysplasia, prominent serration, or diffuse cytoplasmic eosinophilia with any occurrence of the so-called "ectopic crypt formation." We consider pedunculated serrated polyp showing features of SSA/P as a previously undescribed form of serrated adenoma/polyp in the spectrum of serrated neoplasia, which might represent a pedunculated variant of SSA/P or a precursor lesion of proximally located traditional serrated adenomas in the earliest stage.