Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23650363.
- Also identified by DOI 10.1073/pnas.1212976110 and PMC identifier 3666691.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
The peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) controls metabolic adaptations. We now show that PGC-1α in skeletal muscle drives the expression of lactate dehydrogenase (LDH) B in an estrogen-related receptor-α-dependent manner. Concomitantly, PGC-1α reduces the expression of LDH A and one of its regulators, the transcription factor myelocytomatosis oncogene. PGC-1α thereby coordinately alters the composition of the LDH complex and prevents the increase in blood lactate during exercise. Our results show how PGC-1α actively coordinates lactate homeostasis and provide a unique molecular explanation for PGC-1α-mediated muscle adaptations to training that ultimately enhance exercise performance and improve metabolic health.
Medical subject headings
- Estrogen Receptor alpha
- Gene Expression Regulation, Enzymologic
- Homeostasis
- L-Lactate Dehydrogenase
- Lactic Acid
- Muscle Proteins
- Muscle, Skeletal
- Trans-Activators