Bad versus good cholesterol in the bone marrow.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23652105.
- Also identified by DOI 10.1038/nm.3188 and PMC identifier 4164212.
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Abstract
A study now links platelet generation and cholesterol metabolism, providing new understanding of the mechanisms involved in thrombocytosis and atherogenesis. The authors show that the cholesterol transporter ABCG4 is highly expressed in bone marrow megakaryocyte progenitors, and in its absence, these cells have defective cholesterol efflux and increased proliferation, leading to increased megakaryocyte production, thrombocytosis and accelerated atherogenesis in atherosclerosis-prone mice (pages 586–594).
Medical subject headings
- Blood Platelets
- Cholesterol
- Megakaryocytes
- Stem Cells
- Thrombocytosis