Mechanically tunable, self-adjuvanting nanoengineered polypeptide particles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23661596.
- Also identified by DOI 10.1002/adma.201300981.
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Abstract
DNA-loaded polypeptide particles are prepared via templated assembly of mesoporous silica for the delivery of adjuvants. The elasticity and cargo-loading capacity of the obtained particles can be tuned by the amount of cross-linker used to stabilize the polypeptide particles. The use of polypeptide particles as biocarriers provides a promising method for vaccine delivery.
Medical subject headings
- Adjuvants, Immunologic
- Mechanical Phenomena
- Nanotechnology
- Peptides
- Protein Engineering