Comment on "Evidence of abundant purifying selection in humans for recently acquired regulatory functions".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23661742.
- Also identified by DOI 10.1126/science.1233195.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Ward and Kellis (Reports, 28 September 2012, p. 1675; published online 5 September 2012) found altered patterns of human polymorphism in biochemically active but non-mammalian-conserved genomic regions relative to control regions and interpreted this as due to lineage-specific purifying selection. We find on closer inspection of their data that the polymorphism trends are primarily attributable to mutational variation and technical artifacts rather than selection.
Medical subject headings
- Gene Expression Regulation
- Genetic Variation
- Genome, Human
- Regulatory Sequences, Nucleic Acid
- Selection, Genetic