miR-34a and the cardiomyopathy of senescence: SALT PNUTS, SALT PNUTS!
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- Record sourced from PubMed, PMID 23663732.
- Also identified by DOI 10.1016/j.cmet.2013.04.004 and PMC identifier 3676894.
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Abstract
The search for eternal youth is age old. In a recent Nature paper, Boon et al. (2013) describe DNA damage mechanisms and cardiac senescence provoked by miR-34a and its target, PNUTS. Interrupting this pathway may prevent age- and stress-induced cardiac degeneration.