mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23663734.
- Also identified by DOI 10.1016/j.cmet.2013.04.018.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Mechanistic target of rapamycin complex 1 (mTORC1) regulates growth and metabolism by integrating signals from the cellular environment. Ben-Sahra et al. (2013) and Robitaille et al. (2013) demonstrate a role for mTORC1 in nucleotide production via S6K1 phosphorylation of CAD, which catalyzes the initial steps of de novo pyrimidine biosynthesis.