Rejuvenating SIRT1 activators.
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- Record sourced from PubMed, PMID 23663735.
- Also identified by DOI 10.1016/j.cmet.2013.04.016.
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Abstract
Whether the red wine component resveratrol directly activates the NAD(+)-dependent protein deacetylase SIRT1 has been debated. A recent study by Hubbard et al. (2013) strengthens the case that SIRT1-activating compounds (STACs) function as positive allosteric regulators of SIRT1 and thereby regulate mitochondrial function.