Dwelling on T cell fate decisions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23663773.
- Also identified by DOI 10.1016/j.cell.2013.04.026.
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Abstract
Defining determinants of T cell fate is central to understanding adaptive immunity and the design of effective vaccines. Tubo et al. demonstrate that intrinsic properties of T cell receptor signaling dictate whether CD4 T cells adopt predominantly type 1 helper or follicular helper T cell phenotypes in response to bacterial or viral infection.