Differential distribution of the Ca (2+) regulator Pcp4 in the branchial arches is regulated by Hoxa2.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23671666.
- Also identified by DOI 10.1371/journal.pone.0063160 and PMC identifier 3650044.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Branchial arches are externally visible tissue bands in the head region of all vertebrate embryos. Although initially formed from similar components, each arch will give rise to different head and neck structures. In a screen designed to characterize the molecular control of branchial arch identity in mouse, we identified Pcp4 as a second branchial arch-specific molecular signature. We further show that the transcription factor Hoxa2 binds to Pcp4 chromatin and regulates Pcp4 expression in the second arch. Hoxa2 is also sufficient to induce Pcp4 expression in anterior first arch cells, which are Pcp4-negative.
Medical subject headings
- Branchial Region
- Gene Expression Profiling
- Gene Expression Regulation, Developmental
- Homeodomain Proteins
- Nerve Tissue Proteins