BDNF-based synaptic repair as a disease-modifying strategy for neurodegenerative diseases.
review · Level V
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- Record sourced from PubMed, PMID 23674053.
- Also identified by DOI 10.1038/nrn3505.
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Abstract
Increasing evidence suggests that synaptic dysfunction is a key pathophysiological hallmark in neurodegenerative disorders, including Alzheimer's disease. Understanding the role of brain-derived neurotrophic factor (BDNF) in synaptic plasticity and synaptogenesis, the impact of the BDNF Val66Met polymorphism in Alzheimer's disease-relevant endophenotypes - including episodic memory and hippocampal volume - and the technological progress in measuring synaptic changes in humans all pave the way for a 'synaptic repair' therapy for neurodegenerative diseases that targets pathophysiology rather than pathogenesis. This article reviews the key issues in translating BDNF biology into synaptic repair therapies.
Medical subject headings
- Brain-Derived Neurotrophic Factor
- Molecular Targeted Therapy
- Neurodegenerative Diseases
- Neurogenesis
- Neuronal Plasticity
- Synapses