Basolateral BMP signaling in polarized epithelial cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23675417.
- Also identified by DOI 10.1371/journal.pone.0062659 and PMC identifier 3652834.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Bone morphogenetic proteins (BMPs) regulate various biological processes, mostly mediated by cells of mesenchymal origin. However, the roles of BMPs in epithelial cells are poorly understood. Here, we demonstrate that, in polarized epithelial cells, BMP signals are transmitted from BMP receptor complexes exclusively localized at the basolateral surface of the cell membrane. In addition, basolateral stimulation with BMP increased expression of components of tight junctions and enhanced the transepithelial resistance (TER), counteracting reduction of TER by treatment with TGF-β or an anti-tumor drug. We conclude that BMPs maintain epithelial polarity via intracellular signaling from basolaterally localized BMP receptors.
Medical subject headings
- Bone Morphogenetic Protein 4
- Bone Morphogenetic Protein 6
- Bone Morphogenetic Protein Receptors
- Epithelial Cells
- Growth Differentiation Factor 2
- Signal Transduction