Transplant rejection and paradigms lost.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23676457.
- Also identified by DOI 10.1172/JCI69385 and PMC identifier 3668827.
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Abstract
During transplant rejection, migrating T cells infiltrate the grafted organ, but the signals that direct this migration are incompletely understood. In this issue of the JCI, Walch et al. debunk two classical paradigms concerning transplant rejection, with important consequences for the design of antirejection therapeutics.
Medical subject headings
- Antigen Presentation
- CD8-Positive T-Lymphocytes
- Heart Transplantation
- Kidney Transplantation
- Transendothelial and Transepithelial Migration