Crack cocaine use due to dopamine agonist therapy in Parkinson disease.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 23677745.
- Also identified by DOI 10.1212/WNL.0b013e318296e9d5 and PMC identifier 3721099.
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Abstract
Impulse control disorders (ICD)<sup>1</sup> and the dopamine dysregulation syndrome (DDS)<sup>2</sup> are dopaminergic complications of Parkinson disease (PD) treatment. A large number of ICDs have been associated with dopamine agonists (DAA), such as gambling, hypersexuality, and consumerism, but none, to our knowledge, involved drugs of abuse.<sup>1</sup> DDS is a condition in which patients with PD abuse l-dopa, taking it excessively despite the dyskinesias or psychotic symptoms that result.<sup>2</sup> DDS produces l-dopa craving, whereas ICDs produce compulsions, and the 2 may coexist.<sup>2</sup> DDS has rarely been associated with dopamine agonists other than apomorphine.
Medical subject headings
- Cocaine-Related Disorders
- Crack Cocaine
- Dopamine Agonists
- Parkinson Disease