Dual surface-functionalized Janus nanocomposites of polystyrene/Fe₃O₄@SiO₂ for simultaneous tumor cell targeting and stimulus-induced drug release.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23681969.
- Also identified by DOI 10.1002/adma.201301376.
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Abstract
Folic acid (FA) and doxorubicin (DOX) are coupled separately onto Fe3 O4 @SiO2 and polystyrene surfaces of a unique polystyrene/Fe3 O4 @SiO2 Janus structure. This super-paramagnetic, dual-functionalized Janus nanocomposite enables effective tumor cell targeting and internalization via the folate receptor, and induces significant cancer cell death by controlled, stimulus-induced drug release under acidic conditions in endosomal compartments.
Medical subject headings
- Doxorubicin
- Drug Carriers
- Ferrosoferric Oxide
- Nanocomposites
- Polystyrenes
- Silicon Dioxide