Comment on "Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23687029.
- Also identified by DOI 10.1126/science.1237793.
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Abstract
Giovanoli et al. (Reports, 1 March 2013, p. 1095) applied an immune challenge to pregnant females, and therefore to all offspring, and subsequently applied stress to offspring on a per cage basis. The data, however, were analyzed as a completely randomized design, which is inappropriate given these restrictions on randomization. This will increase both false positives and false negatives.
Medical subject headings
- Mental Disorders
- Prenatal Exposure Delayed Effects
- Puberty
- Stress, Physiological