Recombinant supercharged polypeptides restore and improve biolubrication.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23696056.
- Also identified by DOI 10.1002/adma.201300188.
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Abstract
Recombinant supercharged polypeptides (SUPs) with low cytotoxicity are developed and applied to rejuvenate the lubrication of naturally occurring salivary conditioning films (SCFs). SUPs with 72 positive charges adsorbed and rigidified the SCFs and recruited mucins to form a hydrated layer. These SCFs with SUPs have higher mechanical strength and sustain lubricating effect for longer duration compared with only SCFs.
Medical subject headings
- Lubrication
- Peptides
- Recombinant Proteins
- Saliva