The age-related maculopathy susceptibility 2 polymorphism and polypoidal choroidal vasculopathy in Asian populations: a meta-analysis.

Abstract

To assess the role of the age-related maculopathy susceptibility 2 (ARMS2) A69S polymorphism as a risk factor for polypoidal choroidal vasculopathy (PCV) in Asian populations. We performed a meta-analysis of the association of the A69S variant with PCV in Asian populations using data available from 14 case-control studies involving 6552 subjects. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using fixed- and random-effects models. Sensitivity analysis also was performed. Understanding the relationship between the A69S variant and PCV is essential to provide new insights into pathophysiology and potential targets for intervention of PCV. The pooled OR in random-effects models for genotype TG+TT versus wild homozygous genotype GG is 2.39 (95% CI, 1.98-2.89), the OR of heterozygous genotype TG versus GG is 1.66 (95% CI, 1.37-2.00), the OR of homozygous genotype TT versus GG is 4.74 (95% CI, 3.94-5.70), and the OR of allele T versus G is 2.14 (95% CI, 1.79-2.56). A sensitivity analysis indicated the robustness of our findings. Our analysis provides evidence that the A69S variant is associated with an increased risk of PCV in Asian populations. The variant of A69S could be a promising genetic biomarker of PCV. The author(s) have no proprietary or commercial interest in any materials discussed in this article.