ShereKhan--calculating exchange parameters in relaxation dispersion data from CPMG experiments.

Mazur, Adam; Hammesfahr, Björn; Griesinger, Christian; Lee, Donghan; Kollmar, Martin · Bioinformatics · 2013

basic_science · Level V

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Abstract

Dynamics governing the function of biomolecule is usually described as exchange processes and can be monitored at atomic resolution with nuclear magnetic resonance (NMR) relaxation dispersion data. Here, we present a new tool for the analysis of CPMG relaxation dispersion profiles (ShereKhan). The web interface to ShereKhan provides a user-friendly environment for the analysis. A stable version of ShereKhan, the web application and documentation are available at http://sherekhan.bionmr.org. dole@nmr.mpibpc.mpg.de or mako@nmr.mpibpc.mpg.de.

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