Impact of PSCA variation on gastric ulcer susceptibility.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 23704932.
- Also identified by DOI 10.1371/journal.pone.0063698 and PMC identifier 3660579.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Peptic ulcer is one of the most common gastrointestinal disorders with complex etiology. Recently we conducted the genome wide association study for duodenal ulcer and identified disease susceptibility variations at two genetic loci corresponding to the Prostate stem cell antigen (PSCA) gene and the ABO blood group (ABO) gene. Here we investigated the association of these variations with gastric ulcer in two Japanese case-control sample sets, a total of 4,291 gastric ulcer cases and 22,665 controls. As a result, a C-allele of rs2294008 at PSCA increased the risk of gastric ulcer with odds ratio (OR) of 1.13 (P value of 5.85×10(-7)) in an additive model. On the other hand, SNP rs505922 on ABO exhibited inconsistent result between two cohorts. Our finding implies presence of the common genetic variant in the pathogenesis of gastric and duodenal ulcers.
Medical subject headings
- Antigens, Neoplasm
- Genetic Predisposition to Disease
- Neoplasm Proteins
- Polymorphism, Single Nucleotide
- Stomach Ulcer