Transitions for regulating early transcription.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23706732.
- Also identified by DOI 10.1016/j.cell.2013.04.050.
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Abstract
Gene expression is largely regulated during the initiation of RNA polymerase II (PolII) transcription. In this issue, Kouzine et al. show that control of DNA melting is one of the critical rate-limiting steps for productive mRNA elongation. We discuss these findings in the context of other key energetic transitions.
Medical subject headings
- B-Lymphocytes
- Gene Expression Regulation
- Lymphocyte Activation
- Lymphocytes
- Promoter Regions, Genetic