Stearoyl co-A desaturase 1 as a ccRCC therapeutic target: death by stress.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23709675.
- Also identified by DOI 10.1158/1078-0432.CCR-13-0800 and PMC identifier 3898854.
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Abstract
There is a need for the discovery of novel therapeutic strategies to effectively treat advanced clear cell renal cell carcinoma (ccRCC). Inhibition of stearoyl-coA desaturase 1 (SCD1) in ccRCC reveals antitumor activity, independently and in synergy with mTOR inhibition. SCD1 may be a potential novel therapeutic target in treating ccRCC.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma, Renal Cell
- Kidney Neoplasms
- Stearoyl-CoA Desaturase