Enzyme-directed assembly of a nanoparticle probe in tumor tissue.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23712821.
- Also identified by DOI 10.1002/adma.201300823 and PMC identifier 4108424.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Enzyme-directed assembly in vivo: A targeting strategy is demonstrated, which leads to an active accumulation of nanoparticles by virtue of an assembly event specific to endogenous, enzymatic biochemical signals associated with tumor tissue. The viability of this approach is examined through a proof-of-concept study showing enzyme-directed particle targeting and accumulation in human xenograft tumors in mice following intravenous injection, and the retention of particles is demonstrated within tumors for extended periods of time.
Medical subject headings
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- Molecular Probes
- Nanoparticles
- Nanotechnology