A neu view of invasive lobular breast cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23714731.
- Also identified by DOI 10.1158/1078-0432.CCR-13-1031 and PMC identifier 3700640.
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Abstract
Genome sequencing of relapsed, invasive lobular breast cancer identified actionable mutations in 86% of the cases. HER2 alterations occur in 27% of the cases, including 4 cases with activating HER2 mutations and 1 with a novel HER2-GRB7 gene fusion. This fusion links the HER2 tyrosine kinase domain to the GRB7 src homology 2 (SH2) domain.
Medical subject headings
- Breast Neoplasms
- Cadherins
- Carcinoma, Ductal, Breast
- Carcinoma, Lobular
- Mutation
- Erb-b2 Receptor Tyrosine Kinases