miR-506 regulates epithelial mesenchymal transition in breast cancer cell lines.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23717581.
- Also identified by DOI 10.1371/journal.pone.0064273 and PMC identifier 3661463.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Epithelial-mesenchymal transition (EMT) is an important parameter related to breast cancer survival. Among several microRNAs predicted to target EMT-related genes, miR-506 is a novel miRNA found to be significantly related to breast cancer patient survival in a meta-analysis. miR-506 suppressed the expression of mesenchymal genes such as Vimentin, Snai2, and CD151 in MDA-MB-231 human breast cancer cell line. Moreover, NF-κB bound to the upstream promoter region of miR-506 to suppress transcription. Overexpression of miR-506 inhibited TGFβ-induced EMT and suppressed adhesion, invasion, and migration of MDA-MB-231 cells. From these results, we concluded that miR-506 plays a key role in the process of EMT through posttranslational control of EMT-related genes.
Medical subject headings
- Breast Neoplasms
- Epithelial-Mesenchymal Transition
- MicroRNAs