STALing B cell responses with CD22.
Where this comes from
- Record sourced from PubMed, PMID 23722900.
- Also identified by DOI 10.1172/JCI69670 and PMC identifier 3696546.
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Abstract
Suppressing unwanted humoral immune responses without compromising the host's ability to respond to foreign pathogens is a primary goal for therapies aimed at ameliorating harmful autoantibody production. Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can have off-target effects, a limitation to conventional therapies. In this issue of the JCI, Macauley and colleagues utilize a novel platform to inhibit antigen-specific antibody production that preserves the immune system's ability to respond to unrelated antigens.
Medical subject headings
- Apoptosis
- B-Lymphocytes
- Liposomes
- Sialic Acid Binding Ig-like Lectin 2