For better or worse: a niche for Notch in parietal epithelial cell activation.
Level V
Where this comes from
- Record sourced from PubMed, PMID 23728000.
- Also identified by DOI 10.1038/ki.2013.66 and PMC identifier 3671494.
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Abstract
Dysfunction and loss of podocytes (glomerular epithelial cells) are the hallmarks of focal segmental glomerulosclerosis (FSGS). In recent years, activation and proliferation of parietal epithelial cells (PECs) have been increasingly appreciated in FSGS. The functional role of PECs in FSGS is still a hotly debated issue. Ueno et al. report that Notch signaling plays a role in orchestrating PEC phenotypic changes in FSGS.
Medical subject headings
- Epithelial Cells
- Glomerulosclerosis, Focal Segmental
- Kidney Glomerulus
- Podocytes
- Receptor, Notch1