Patient-derived tumor xenografts: transforming clinical samples into mouse models.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23733750.
- Also identified by DOI 10.1158/0008-5472.CAN-13-1069 and PMC identifier 3766500.
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Abstract
Tumor graft models (also known as patient-derived xenografts or PDX) are based on the transfer of primary tumors directly from the patient into an immunodeficient mouse. Because PDX mice are derived from human tumors, they offer a tool for developing anticancer therapies and personalized medicine for patients with cancer. In addition, these models can be used to study metastasis and tumor genetic evolution. This review examines the development, challenges, and broad use of these attractive preclinical models.
Medical subject headings
- Cell Transformation, Neoplastic
- Disease Models, Animal
- Neoplasms