Glucanase induces filamentation of the fungal pathogen Candida albicans.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23737947.
- Also identified by DOI 10.1371/journal.pone.0063736 and PMC identifier 3667860.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta-glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.
Medical subject headings
- Candida albicans
- Glucan 1,3-beta-Glucosidase