WhichCyp: prediction of cytochromes P450 inhibition.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23740742.
- Also identified by DOI 10.1093/bioinformatics/btt325.
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Abstract
In this work we present WhichCyp, a tool for prediction of which cytochromes P450 isoforms (among 1A2, 2C9, 2C19, 2D6 and 3A4) a given molecule is likely to inhibit. The models are built from experimental high-throughput data using support vector machines and molecular signatures. The WhichCyp server is freely available for use on the web at http://drug.ku.dk/whichcyp, where the WhichCyp Java program and source code is also available for download.
Medical subject headings
- Cytochrome P-450 Enzyme Inhibitors
- Enzyme Inhibitors
- Software