Triplex-Inspector: an analysis tool for triplex-mediated targeting of genomic loci.
Where this comes from
- Record sourced from PubMed, PMID 23740745.
- Also identified by DOI 10.1093/bioinformatics/btt315 and PMC identifier 3712220.
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Abstract
At the heart of many modern biotechnological and therapeutic applications lies the need to target specific genomic loci with pinpoint accuracy. Although landmark experiments demonstrate technological maturity in manufacturing and delivering genetic material, the genomic sequence analysis to find suitable targets lags behind. We provide a computational aid for the sophisticated design of sequence-specific ligands and selection of appropriate targets, taking gene location and genomic architecture into account. Source code and binaries are downloadable from www.bioinformatics.org.au/triplexator/inspector. t.bailey@uq.edu.au Supplementary data are available at Bioinformatics online.
Medical subject headings
- DNA
- Gene Targeting
- Software