Dual PI3K/mTOR inhibitors: does p53 modulate response?
Where this comes from
- Record sourced from PubMed, PMID 23741068.
- Also identified by DOI 10.1158/1078-0432.CCR-13-1291.
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Abstract
Head and neck squamous cell carcinomas have multiple genetic alterations that can influence clinical response to treatment. It is important to evaluate how distinct alterations affect response to targeted agents to identify a subset of patients who can benefit from therapy, improving survival and decreasing toxicity.
Medical subject headings
- Antineoplastic Agents
- Carcinoma, Squamous Cell
- Head and Neck Neoplasms
- Pyridones
- Pyrimidines
- Tumor Suppressor Protein p53