Monocyte and macrophage heterogeneity in the heart.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23743228.
- Also identified by DOI 10.1161/CIRCRESAHA.113.300890 and PMC identifier 3753681.
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Abstract
Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and their tenure may range between hours and months. Some subsets are highly inflammatory, whereas others support tissue repair. This review discusses current concepts of lineage relationships and crosstalk of systems, highlights open questions, and describes tools for studying monocyte and macrophage subsets in the murine and human heart.
Medical subject headings
- Heart Failure
- Macrophages
- Monocytes
- Myocardial Infarction
- Myocardium