Glucagon's yin and yang effects on hepatic glucose production.
basic_science · Level V
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- Record sourced from PubMed, PMID 23744146.
- Also identified by DOI 10.1038/nm.3202 and PMC identifier 5407006.
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Abstract
New insights into the actions of the hormone glucagon are provided by a recent study in rodents, which shows that glucagon can suppress hepatic glucose production by acting through the mediobasal hypothalamic region of the brain. This central regulatory mechanism is impaired in rats fed a high-fat diet, suggesting that hypothalamic glucagon resistance may be relevant to the hyperglycemia observed in obesity, diabetes or both (pages 766–772).
Medical subject headings
- Glucagon
- Glucose
- Hypothalamus
- Liver
- Signal Transduction