This message will self-destruct: NMD regulates axon guidance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746834.
- Also identified by DOI 10.1016/j.cell.2013.05.019 and PMC identifier 3703776.
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Abstract
The navigation of axons to their final destination can involve a sequence of steps that require different sets of guidance receptors. In this issue, Colak et al. show that regulated intra-axonal protein synthesis coupled to nonsense-mediated mRNA decay (NMD) controls a switch in Robo3.2 expression that is critical for navigation.
Medical subject headings
- Axons
- Embryo, Mammalian
- Growth Cones
- Membrane Proteins
- Nerve Tissue Proteins
- Nonsense Mediated mRNA Decay
- Spinal Cord