A new DUB makes linear ubiquitin a party to its own destruction.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746836.
- Also identified by DOI 10.1016/j.cell.2013.05.018.
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Abstract
Linear ubiquitin (Ub) plays a role in nuclear factor κB signaling, but the deubiquitinating enzyme that disassembles these chains was unknown. In this issue of Cell, Keusekotten et al. identify a new enzyme that disassembles linear chains with the use of a mechanism that relies on Ub itself to help catalyze peptide bond cleavage.
Medical subject headings
- Endopeptidases