Fixing a hole where the Ras gets in.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746837.
- Also identified by DOI 10.1016/j.cell.2013.05.029.
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Abstract
A clinically efficacious Ras inhibitor has eluded drug-discovery efforts for decades. In a paper in Nature, Zimmermann and et al. show that blocking a hole in PDEδ that normally engages the lipid tail of Ras disrupts downstream signaling, pointing to a potentially promising route to develop Ras inhibitors for cancer treatment.
Medical subject headings
- Benzimidazoles
- Cyclic Nucleotide Phosphodiesterases, Type 6
- Oncogene Protein p21(ras)
- Signal Transduction