Candidate ALS therapeutics motor toward "in vitro clinical trials".
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746968.
- Also identified by DOI 10.1016/j.stem.2013.05.009.
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Abstract
Conducting drug discovery efforts in patient- and disease-specific cells can maximize their likelihood of success. In this issue of Cell Stem Cell, Yang et al. (2013) demonstrate the power of lineage-specific cell-based drug screens by identifying a compound that promotes survival of stem-cell-derived ALS mutant motor neurons.
Medical subject headings
- Amyotrophic Lateral Sclerosis
- Embryonic Stem Cells
- Glycogen Synthase Kinase 3
- Induced Pluripotent Stem Cells
- Intracellular Signaling Peptides and Proteins
- Motor Neurons
- Protein Kinase Inhibitors
- Protein Serine-Threonine Kinases