The other face of ROS: a driver of stem cell expansion in colorectal cancer.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746969.
- Also identified by DOI 10.1016/j.stem.2013.05.023.
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Abstract
APC mutations causing Wnt activation are commonly found in colorectal cancer, but downstream pathways that facilitate tumorigenesis are unclear. In this issue of Cell Stem Cell, Myant et al. (2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.
Medical subject headings
- Colorectal Neoplasms
- Intestine, Small
- NF-kappa B
- Neuropeptides
- Reactive Oxygen Species
- Stem Cells
- Wnt Proteins
- rac1 GTP-Binding Protein