Unraveling tumor suppressor networks with in vivo RNAi.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746971.
- Also identified by DOI 10.1016/j.stem.2013.05.020.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
Medical subject headings
- Bone Morphogenetic Proteins
- Endoplasmic Reticulum Stress
- Glioblastoma
- Neoplastic Stem Cells
- Polycomb Repressive Complex 1
- Proto-Oncogene Proteins
- Transforming Growth Factor beta