Therapeutic translation of iPSCs for treating neurological disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23746977.
- Also identified by DOI 10.1016/j.stem.2013.05.018.
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Abstract
Somatic cellular reprogramming is a fast-paced and evolving field that is changing the way scientists approach neurological diseases. For the first time in the history of neuroscience, it is feasible to study the behavior of live neurons from patients with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, and neuropsychiatric diseases, such as autism and schizophrenia. In this Perspective, we will discuss reprogramming technology in the context of its potential use for modeling and treating neurological and psychiatric diseases and will highlight areas of caution and opportunities for improvement.
Medical subject headings
- Nervous System Diseases
- Pluripotent Stem Cells