Does a single nucleotide polymorphism in the FGFR explain the connection between diabetes and cancer?
expert_opinion · Level V
Where this comes from
- Record sourced from PubMed, PMID 23747238.
- Also identified by DOI 10.1016/j.cmet.2013.05.006.
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Abstract
A polymorphism in the fibroblast growth factor receptor 4 gene has been associated with cancer progression and treatment resistance and is now reported to increase insulin secretion, providing a possible genetic link between hyperinsulinemia and cancer (Ezzat et al., 2013).
Medical subject headings
- Insulin
- Proteins
- Receptor, Fibroblast Growth Factor, Type 4
- STAT3 Transcription Factor
- STAT5 Transcription Factor