Metformin, microbes, and aging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23747239.
- Also identified by DOI 10.1016/j.cmet.2013.05.014.
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Abstract
The mechanisms underlying the biological activity of metformin, a widely prescribed drug to treat type 2 diabetes, remain elusive. In a recent issue of Cell, Cabreiro et al. report that in C. elegans, metformin indirectly impacts lifespan by altering the methionine metabolism of its microbial partner E. coli (Cabreiro et al., 2013).
Medical subject headings
- Caenorhabditis elegans
- Folic Acid
- Hypoglycemic Agents
- Longevity
- Metformin
- Methionine