A radical signal activates the epigenetic regulation of longevity.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 23747240.
- Also identified by DOI 10.1016/j.cmet.2013.05.015.
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Abstract
Hormesis is an adaptive stress response implicated in longevity regulation. Schroeder et al. (2013) have now connected stress, epigenetic changes, and aging in yeast by showing that mitochondria-derived reactive oxygen species modulate the chromatin binding capacity of the histone demethylase Rph1p at subtelomeres, resulting in lifespan extension.
Medical subject headings
- Cell Cycle Proteins
- Checkpoint Kinase 2
- DNA Repair
- Intracellular Signaling Peptides and Proteins
- Longevity
- Mitochondria
- Protein Serine-Threonine Kinases
- Saccharomyces cerevisiae Proteins