Agitation by suffocation: how hypoxia activates innate immunity via the Warburg effect.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 23747241.
- Also identified by DOI 10.1016/j.cmet.2013.05.016.
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Abstract
A hypoxic microenvironment can enhance the function of innate immune cells; however, the mechanisms remain unclear. Tannahill et al. (2013) find that in macrophages, the accumulation of succinate, an intermediate metabolite of the tricarboxylic acid cycle, stabilizes the transcription factor HIF-1α, leading to activation of the proinflammatory cytokine IL-1β.
Medical subject headings
- Hypoxia-Inducible Factor 1, alpha Subunit
- Interleukin-1beta
- Signal Transduction
- Succinic Acid