The relationship between metabolism and the autophagy machinery during the innate immune response.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 23747248.
- Also identified by DOI 10.1016/j.cmet.2013.05.012 and PMC identifier 3696504.
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Abstract
The innate immune response is shaped by multiple factors, including both traditional autophagy and LC3-associated phagocytosis (LAP). As the autophagic machinery is engaged during times of nutrient stress, arising from scarcity or pathogens, we examine how autophagy, specifically LAP, and cellular metabolism together influence macrophage function and the innate immune response.
Medical subject headings
- Autophagy
- Energy Metabolism
- Microtubule-Associated Proteins
- Phagocytosis