Role of murine intestinal interleukin-1 receptor 1-expressing lymphoid tissue inducer-like cells in Salmonella infection.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 23750260.
- Also identified by DOI 10.1371/journal.pone.0065405 and PMC identifier 3672157.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Interleukin (IL)-1 signaling plays a critical role in intestinal immunology. Here, we report that the major population of intestinal lamina propria lymphocytes expressing IL-1 receptor 1 (IL-1R1) is the lymphoid tissue inducer (LTi)-like cell, a type of innate lymphoid cell. These cells are significant producers of IL-22, and this IL-22 production depends on IL-1R1 signaling. LTi-like cells are required for defense against Salmonella enterica serovar Typhimurium. Moreover, colonic LTi-like cell numbers depend on the presence of the intestinal microbiota. LTi-like cells require IL-1R1 for production of protective cytokines and confer protection in infectious colitis, and their cell numbers in the colon depend upon having a microbiome.
Medical subject headings
- Gene Expression Regulation
- Intestines
- Lymphoid Tissue
- Receptors, Interleukin-1 Type I
- Salmonella Infections
- Salmonella typhimurium
- T-Lymphocytes, Helper-Inducer