Persistent inflammation and endothelial activation in HIV-1 infected patients after 12 years of antiretroviral therapy.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 23755191.
- Also identified by DOI 10.1371/journal.pone.0065182 and PMC identifier 3670840.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The study investigated markers of inflammation and endothelial activation in HIV infected patients after 12 years of successful combination antiretroviral treatment (cART). Inflammation and endothelial activation were assessed by measuring levels of immunoglobulins, β2-microglobulin, interleukin (IL) 8, tumor necrosis factor α (TNFα), vascular cell adhesion molecule-1 (sVCAM-1), intercellular adhesion molecule-1 (sICAM-1), sE-Selectin, and sP-Selectin. HIV infected patients had higher levels of β2-microglobulin, IL-8, TNFα, and sICAM-1 than uninfected controls, and HIV infected patients lacked correlation between platelet counts and sP-Selectin levels found in uninfected controls. Discrete signs of systemic and vascular inflammation persist even after very long term cART.
Medical subject headings
- Anti-Retroviral Agents
- Endothelium, Vascular
- HIV Infections